Estado nutricional como preditor de qualidade de vida em pacientes em hemodiálise / Nutritional status as predictor of quality of life in patients undergoing hemodialysis / Estado nutricional como predictor de calidad de vida en pacientes en hemodiálisis

Objetivo: avaliar a associação entre qualidade de vida e estado nutricional de pacientes em hemodiálise, segundo medidas antropométricas e bioquímicas. Métodos: estudo transversal realizado com 1.024 pacientes de 11 centros de hemodiálise de uma região metropolitana da região sudeste do Brasil. Resultados: por meio da regressão linear múltipla, foram identificados os preditores nutricionais de cada domínio da qualidade de vida. Destacamos a albumina sérica, o Índice de Massa Corporal (IMC) e a circunferência da cintura, dentre as medidas associadas tanto a saúde física quanto a mental desta população. Conclusão: a inadequação do estado nutricional está associada a pior qualidade de vida física e mental de indivíduos em hemodiálise. Além do monitoramento do estado nutricional, a avaliação nutricional prediz a qualidade de vida e torna-se uma ferramenta fundamental para um melhor desfecho de saúde, uma vez que a baixa qualidade de vida é um dos principais problemas desta população.

Objective: to evaluate the association between quality of life and nutritional status of hemodialysis patients, according to anthropometric and biochemical measurements. Methods: cross-sectional study conducted with 1,024 patients from 11 hemodialysis centers in a metropolitan region of southeastern Brazil. Results: through multiple linear regression, the nutritional predictors of each domain of quality of life were identified. We highlight serum albumin, Body Mass Index (BMI) and waist circumference, among the measures associated with both physical and mental health in this population. Conclusion: inadequate nutritional status is associated with worse physical and mental quality of life in hemodialysis individuals. In addition to monitoring the nutritional status, nutritional assessment predicts quality of life and becomes a fundamental tool for a better health outcome, since low quality of life is one of the main problems in this population.

Objetivo: evaluar la asociación entre calidad de vida y estado nutricional de pacientes en hemodiálisis, según medidas antropométricas y bioquímicas. Métodos: estudio transversal realizado con 1.024 pacientes de 11 centros de hemodiálisis de una región metropolitana del sureste de Brasil. Resultados: mediante regresión lineal múltiple, se identificaron los predictores nutricionales de cada dominio de la calidad de vida. Destacamos la albúmina sérica, el índice de masa corporal (IMC) y la circunferencia de la cintura, entre las medidas asociadas a la salud tanto física como mental en esta población. Conclusión: el estado nutricional inadecuado se asocia con una peor calidad de vida física y mental en los individuos en hemodiálisis. Además de monitorear el estado nutricional, la evaluación nutricional predice la calidad de vida y se convierte en una herramienta fundamental para un mejor resultado de salud, ya que la baja calidad de vida es uno de los principales problemas en esta población.

Clinical Features and Risk Factors of Systemic Lupus Erythematosus Complicated with Cytomegalovirus Infection / 中国医学科学院学报

Objective To explore the clinical characteristics and risk factors of systemic lupus erythematosus(SLE)complicated with cytomegalovirus infection(CMV). Methods The medical records of patients diagnosed with SLE at discharge in the Department of Immunology at Peking Union Medical College Hospital between July 1,2017 and April 1,2019 were retrospectively reviewed,and the clinical and laboratory data related to CMV infection were analyzed. Results Of the 231 patients with SLE,115(49.8%)had CMV infection.Among them,78(67.8%)were asymptomatic CMV infection and 37(32.2%)were diagnosed with CMV disease.Univariate analysis showed the number of organs involved(

Effect of spironolactone on the progression of coronary calcification in peritoneal dialysis patients: a pilot study / Efeito da espironolactona na progressão da calcificação coronariana em pacientes em diálise peritoneal: um estudo piloto

ABSTRACT Introduction: There is evidence that aldosterone plays a role in the pathogenesis of vascular calcification. The aim of this study was to evaluate the effect of spironolactone, a mineralocorticoid receptor antagonist, on the progression of coronary calcification (CC) in peritoneal dialysis patients and to identify the factors involved in this progression. Methods: Thirty-three patients with a coronary calcium score (CCS) ≥ 30, detected through multi-detector computed tomography (MDCT) and expressed in Agatston units, were randomly assigned to a group receiving 25mg spironolactone per day for 12 months (spironolactone group) and a control group not receiving this drug. The primary outcome was a percentage change in CCS from baseline to end of the study (relative progression), when a further MDCT was conducted. Patients who had progression of CC were compared with those who did not progress. Results: Sixteen patients, seven in the spironolactone group and nine in the control group, concluded the study. The relative progression of the CCS was similar in both groups, 17.2% and 27.5% in the spironolactone and control groups respectively. Fifty-seven percent of the treated patients and 67% of those in the control group presented progression in the CC scores (p = 0.697). Progressor patients differed from non-progressors because they presented higher levels of calcium and low-density lipoprotein cholesterol and lower levels of albumin. Conclusion: In peritoneal dialysis patients, spironolactone did not attenuate the progression of CC. However, large-scale studies are needed to confirm this observation. Disorders of mineral metabolism and dyslipidemia are involved in the progression of CC.

RESUMO Introdução: Existem evidências de que a aldosterona exerça um papel na patogênese da calcificação vascular. O objetivo deste estudo foi avaliar o efeito da espironolactona, um antagonista do receptor mineralocorticoide, na progressão da calcificação coronariana (CC) de pacientes em diálise peritoneal, e identificar os fatores envolvidos nessa progressão. Métodos: Trinta e três pacientes com escore de cálcio coronariano (ECC) ≥ 30, detectado por tomografia computadorizada com múltiplos detectores (TCMD) e expresso em unidades de Agatston, foram randomizados para um grupo que recebeu 25 mg de espironolactona por dia durante 12 meses (grupo espironolactona) e um grupo controle que não recebeu este medicamento. O desfecho primário foi a mudança percentual do ECC do início para o final do estudo (progressão relativa), quando uma nova TCMD foi realizada. Os pacientes que tiveram progressão de CC foram comparados com aqueles que não progrediram. Resultados: Dezesseis pacientes, sete no grupo espironolactona e nove no grupo controle, concluíram o estudo. A progressão relativa do ECC foi semelhante nos dois grupos, 17,2% e 27,5% nos grupos espironolactona e controle, respectivamente. Cinquenta e sete por cento dos pacientes tratados e 67% daqueles no grupo controle apresentaram progressão nos escores de CC (p = 0,697). Os pacientes progressores diferiram dos não progressores porque apresentaram níveis séricos mais elevados de cálcio e LDL-colesterol e menores níveis de albumina. Conclusão: Em pacientes em diálise peritoneal, a espironolactona não atenuou a progressão da CC. No entanto, estudos em grande escala são necessários para confirmar essa observação. Distúrbios do metabolismo mineral e dislipidemia estão envolvidos na progressão da CC.

Logistic regression analysis of clinical and computed tomography features of pulmonary abscesses and risk factors for pulmonary abscess-related empyema

OBJECTIVES: This study was conducted to investigate the risk factors for pulmonary abscess-related empyema by investigating the clinical characteristics and chest computed tomography imaging features of patients with pulmonary abscesses. METHODS: We retrospectively analyzed the chest computed tomography findings and clinical features of 101 cases of pulmonary abscess, including 25 cases with empyema (the experimental group) and 76 cases with no empyema (the control group). The potential risk factors for pulmonary abscess-related empyema were compared between the groups by using univariate and multivariate logistic regression analyses. RESULTS: The incidence of pulmonary abscess-related empyema was 24.8% (25/101). Univariate analysis showed that male gender, diabetes, pleuritic symptoms, white blood cells >10×109/L, albumin level <25 g/L, and positive sputum cultures were potential clinical-related risk factors and that an abscess >5 cm in diameter and transpulmonary fissure abscesses were potential computed tomography imaging-related risk factors for pulmonary abscess-related empyema. Multivariate logistic regression analysis showed that transpulmonary fissure abscesses (odds ratio=9.102, p=0.003), diabetes (odds ratio=9.066, p=0.003), an abscess >5 cm in diameter (odds ratio=8.998, p=0.002), and pleuritic symptoms (odds ratio=5.395, p=0.015) were independent risk factors for pulmonary abscess-related empyema. CONCLUSIONS: Transpulmonary fissure abscesses, diabetes, giant pulmonary abscesses, and pleuritic symptoms increased the risk of empyema among patients with pulmonary abscesses.